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Tough Composite Hydrogels with High Loading and Local Release of Biological Drugs.
- Source :
-
Advanced healthcare materials [Adv Healthc Mater] 2018 May; Vol. 7 (9), pp. e1701393. Date of Electronic Publication: 2018 Feb 14. - Publication Year :
- 2018
-
Abstract
- Hydrogels are under active development for controlled drug delivery, but their clinical translation is limited by low drug loading capacity, deficiencies in mechanical toughness and storage stability, and poor control over the drug release that often results in burst release and short release duration. This work reports a design of composite clay hydrogels, which simultaneously achieve a spectrum of mechanical, storage, and drug loading/releasing properties to address the critical needs from translational perspectives. The clay nanoparticles provide large surface areas to adsorb biological drugs, and assemble into microparticles that are physically trapped within and toughen hydrogel networks. The composite hydrogels demonstrate feasibility of storage, and extended release of large quantities of an insulin-like growth factor-1 mimetic protein (8 mg mL <superscript>-1</superscript> ) over four weeks. The release rate is primarily governed by ionic exchange and can be upregulated by low pH, which is typical for injured tissues. A rodent model of Achilles tendon injury is used to demonstrate that the composite hydrogels allow for highly extended and localized release of biological drugs in vivo, while demonstrating biodegradation and biocompatibility. These attributes make the composite hydrogel a promising system for drug delivery and regenerative medicine.<br /> (© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
- Subjects :
- Animals
Delayed-Action Preparations chemistry
Delayed-Action Preparations pharmacokinetics
Delayed-Action Preparations pharmacology
Female
Humans
Mice
NIH 3T3 Cells
Rats
Rats, Sprague-Dawley
Achilles Tendon metabolism
Achilles Tendon pathology
Biomimetic Materials chemistry
Biomimetic Materials pharmacokinetics
Biomimetic Materials pharmacology
Drug Carriers chemistry
Drug Carriers pharmacokinetics
Drug Carriers pharmacology
Hydrogels chemistry
Hydrogels pharmacokinetics
Hydrogels pharmacology
Insulin-Like Growth Factor I
Peptides chemistry
Peptides pharmacokinetics
Peptides pharmacology
Tendon Injuries drug therapy
Tendon Injuries metabolism
Tendon Injuries pathology
Subjects
Details
- Language :
- English
- ISSN :
- 2192-2659
- Volume :
- 7
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Advanced healthcare materials
- Publication Type :
- Academic Journal
- Accession number :
- 29441702
- Full Text :
- https://doi.org/10.1002/adhm.201701393