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Incorporation of Nonproteinogenic Amino Acids in Class I and II Lantibiotics.
- Source :
-
ACS chemical biology [ACS Chem Biol] 2018 Apr 20; Vol. 13 (4), pp. 951-957. Date of Electronic Publication: 2018 Feb 21. - Publication Year :
- 2018
-
Abstract
- Lantibiotics are ribosomally synthesized and post-translationally modified peptide natural products that contain thioether cross-links formed by lanthionine and methyllanthionine residues. They exert potent antimicrobial activity against Gram-positive bacteria. We herein report production of analogues of two lantibiotics, lacticin 481 and nisin, that contain nonproteinogenic amino acids using two different strategies involving amber stop codon suppression technology. These methods complement recent alternative approaches to incorporate nonproteinogenic amino acids into lantibiotics.
Details
- Language :
- English
- ISSN :
- 1554-8937
- Volume :
- 13
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- ACS chemical biology
- Publication Type :
- Academic Journal
- Accession number :
- 29439566
- Full Text :
- https://doi.org/10.1021/acschembio.7b01024