High Genetic Plasticity in Multidrug-Resistant Sequence Type 3-IncHI2 Plasmids Revealed by Sequence Comparison and Phylogenetic Analysis.

Authors :: Fang LX
Li XP
Deng GH
Li SM
Yang RS
Wu ZW
Liao XP
Sun J
Liu YH
Source :: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2018 Mar 27; Vol. 62 (4). Date of Electronic Publication: 2018 Mar 27 (Print Publication: 2018).
Publication Year :: 2018
Abstract: We report a novel fusion plasmid, pP2-3T, cointegrating sequence type 3 (ST3)-IncHI2 with an IncFII plasmid backbone mediating multidrug resistance (MDR) and virulence. Phylogenetic analysis and comparative genomics revealed that pP2-3T and other MDR ST3-IncHI2 plasmids clustered together, representing a unique IncHI2 lineage that exhibited high conservation in backbones of plasmids but possessed highly genetic plasticity in various regions by acquiring numerous antibiotic resistance genes and fusing with other plasmids. Surveillance studies should be performed to monitor multiresistance IncHI2 plasmids among Enterobacteriaceae .<br /> (Copyright © 2018 American Society for Microbiology.)

Subjects :: Genomics
Microbial Sensitivity Tests
Sequence Analysis, DNA methods
Virulence genetics
Drug Resistance, Multiple, Bacterial genetics
Phylogeny
Plasmids genetics

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