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Brain tissue plasticity: protein synthesis rates of the human brain.
- Source :
-
Brain : a journal of neurology [Brain] 2018 Apr 01; Vol. 141 (4), pp. 1122-1129. - Publication Year :
- 2018
-
Abstract
- All tissues undergo continuous reconditioning via the complex orchestration of changes in tissue protein synthesis and breakdown rates. Skeletal muscle tissue has been well studied in this regard, and has been shown to turnover at a rate of 1-2% per day in vivo in humans. Few data are available on protein synthesis rates of other tissues. Because of obvious limitations with regard to brain tissue sampling no study has ever measured brain protein synthesis rates in vivo in humans. Here, we applied stable isotope methodology to directly assess protein synthesis rates in neocortex and hippocampus tissue of six patients undergoing temporal lobectomy for drug-resistant temporal lobe epilepsy (Clinical trial registration: NTR5147). Protein synthesis rates of neocortex and hippocampus tissue averaged 0.17 ± 0.01 and 0.13 ± 0.01%/h, respectively. Brain tissue protein synthesis rates were 3-4-fold higher than skeletal muscle tissue protein synthesis rates (0.05 ± 0.01%/h; P < 0.001). In conclusion, the protein turnover rate of the human brain is much higher than previously assumed.
- Subjects :
- Adult
Brain surgery
Carbon Isotopes
Epilepsy, Temporal Lobe blood
Epilepsy, Temporal Lobe surgery
Female
Humans
Male
Middle Aged
Neuronavigation
Neurosurgical Procedures methods
Phenylalanine metabolism
Time Factors
Brain physiopathology
Epilepsy, Temporal Lobe pathology
Neuronal Plasticity physiology
Proteins metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1460-2156
- Volume :
- 141
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Brain : a journal of neurology
- Publication Type :
- Academic Journal
- Accession number :
- 29432531
- Full Text :
- https://doi.org/10.1093/brain/awy015