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Immunocryosurgery as monotherapy for lentigo maligna or combined with surgical excision for lentigo maligna melanoma.
- Source :
-
The Journal of dermatology [J Dermatol] 2018 May; Vol. 45 (5), pp. 564-570. Date of Electronic Publication: 2018 Feb 11. - Publication Year :
- 2018
-
Abstract
- The incidence of lentigo maligna (LM), in situ (LM) or invasive (lentigo maligna melanoma, LMM), has increased during the last decades. Due to functional or cosmetic outcomes, optimal treatment with surgical excision may not be appropriate in some cases. We tried less invasive therapy, immunocryosurgery, as a single treatment for LM or combined with surgery for LMM, with better aesthetic results. Three patients with LM or LMM not amenable to complete surgical excision were selected. LMM patients underwent limited surgical resection of the invasive area. Subsequently, a combined treatment with topical imiquimod and cryosurgery was performed. The LM patient received immunocryosurgery directly. All of them were free of local and systemic disease at 48, 42 and 41 months after discontinuation of therapy. We consider that immunocryosurgery is an alternative option for LM or even for LMM (after removal of the invasive tissue with narrow margins) in poor surgical candidates, with good therapeutic, functional and cosmetic results.<br /> (© 2018 Japanese Dermatological Association.)
- Subjects :
- Adjuvants, Immunologic therapeutic use
Administration, Cutaneous
Aged
Aged, 80 and over
Aminoquinolines therapeutic use
Biopsy
Combined Modality Therapy adverse effects
Combined Modality Therapy methods
Cryosurgery adverse effects
Dermatologic Surgical Procedures adverse effects
Dermatologic Surgical Procedures methods
Female
Humans
Hutchinson's Melanotic Freckle pathology
Imiquimod
Immunotherapy adverse effects
Melanoma pathology
Skin pathology
Skin Cream therapeutic use
Skin Neoplasms pathology
Cryosurgery methods
Hutchinson's Melanotic Freckle therapy
Immunotherapy methods
Melanoma therapy
Skin Neoplasms therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1346-8138
- Volume :
- 45
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- The Journal of dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 29430695
- Full Text :
- https://doi.org/10.1111/1346-8138.14248