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Age and HIV effects on resting state of the brain in relationship to neurocognitive functioning.
- Source :
-
Behavioural brain research [Behav Brain Res] 2018 May 15; Vol. 344, pp. 20-27. Date of Electronic Publication: 2018 Feb 06. - Publication Year :
- 2018
-
Abstract
- This study examined the effects of age and HIV infection on the resting state (RS) functional connectivity (FC) of the brain and cognitive functioning. The objective was to evaluate the moderating role of age and HIV on the relationship between RS-FC and cognition. To examine RS-FC we implemented the Independent Component Analysis (ICA) and Regional Homogeneity (ReHo). Neurocognition was evaluated with comprehensive battery of standardized neuropsychological tests. Age and HIV were entered as the independent variables. The independent effects of age, HIV, and interaction effects of age-HIV on RS-fMRI measures (ICA, ReHo) were tested in 108 participants (age M = 42). RS-FC indices that exhibited age-HIV interactions were entered into further analysis. Bivariate correlation analysis was performed between the retained RS-FC indices and T-scores of neurocognitive domains (Attention, Executive, Memory, Psychomotor, Semantic Skills). Multivariate regression modeling determined the impact of age and HIV on these relationships. We found that in the ICA measures, HIV-seropositivity was decreasing RS-FC in the left middle occipital gyrus (p < .001). Age-HIV interaction was observed in the left superior frontal gyrus (LSupFrontG), where FC was decreasing with age in HIV+ (p < .001) and increasing in HIV- (p = .031). ReHo indices did not reveal significant effects. HIV strengthened the relationship between RS-FC in LSupFrontG, Memory and Psychomotor Factor scores. Aging weakened those relationships only in control group. In sum, age-HIV interaction effects are prominent rather in remote than local RS-FC. Seroconversion strengthens relationships between intrinsic brain activity and neurocognition, but no acceleration with years of age was noted in HIV+ individuals.<br /> (Copyright © 2018 Elsevier B.V. All rights reserved.)
- Subjects :
- Adult
Aged
Brain diagnostic imaging
Brain physiology
Brain Mapping
Cognition Disorders diagnostic imaging
Cognition Disorders etiology
Cognition Disorders physiopathology
Cohort Studies
HIV Infections diagnostic imaging
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Multivariate Analysis
Neural Pathways diagnostic imaging
Neural Pathways physiology
Neural Pathways physiopathology
Neuropsychological Tests
Regression Analysis
Rest
Aging physiology
Aging psychology
Brain physiopathology
Cognition physiology
HIV Infections physiopathology
HIV Infections psychology
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7549
- Volume :
- 344
- Database :
- MEDLINE
- Journal :
- Behavioural brain research
- Publication Type :
- Academic Journal
- Accession number :
- 29425918
- Full Text :
- https://doi.org/10.1016/j.bbr.2018.02.007