Triterpenoids from the leaves of Ilex chinensis.

Authors :: Xia WQ
Li RF
Liu JB
Cui BS
Hou Q
Sun H
Li S
Source :: Phytochemistry [Phytochemistry] 2018 Apr; Vol. 148, pp. 113-121. Date of Electronic Publication: 2018 Feb 06.
Publication Year :: 2018
Abstract: Eleven previously undescribed compounds including two triterpenes, ilexchinenin A and ilexchinenin B, and nine triterpenoid saponins, ilexchinenosides A-I, along with twelve known triterpenoids were isolated from the leaves of Ilex chinensis Sims (Aquifoliaceae). Their structures were elucidated by spectroscopic analysis and comparison with known compounds. Furthermore, eight compounds exhibited significant inhibitory effects on NO production of lipopolysaccharide (LPS)-induced murine macrophages, while nine compounds exhibited potent hepatoprotective activity against N-acetyl-p-aminophenol (APAP)-induced HepG2 cell damage in in vitro assays.<br /> (Copyright © 2018 Elsevier Ltd. All rights reserved.)