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Activation of mast cells in skin abscess induced by Staphylococcus aureus (S. aureus) infection in mice.
- Source :
-
Research in veterinary science [Res Vet Sci] 2018 Jun; Vol. 118, pp. 66-71. Date of Electronic Publication: 2018 Jan 31. - Publication Year :
- 2018
-
Abstract
- The skin abscess is a common inflammatory disease that occurs following the ubiquitous S. aureus infection. In our study, a skin abscess murine model was established and the dynamics of mast cells chemotaxing was evaluated. In the S. aureus-infected mice, severe infiltration of inflammatory cells in the dermis were observed, and mast cells were markedly accumulated in the skins. Besides, tryptase, the marker for mast cells activation, has a positive correlation with mast cell activity. The mast cells identified in the tissues were likely to be activated since they were associated with cell degranulation and the presence of tryptase. Our results suggested that mast cells and its mediator tryptase contribute to the inflammation of skin abscess induced by S. aureus infection.<br /> (Copyright © 2018 Elsevier Ltd. All rights reserved.)
- Subjects :
- Abscess immunology
Abscess microbiology
Animals
Mast Cells immunology
Mast Cells physiology
Mice
Skin
Skin Diseases immunology
Skin Diseases microbiology
Staphylococcal Infections immunology
Abscess veterinary
Mast Cells cytology
Skin Diseases veterinary
Staphylococcal Infections veterinary
Staphylococcus aureus pathogenicity
Subjects
Details
- Language :
- English
- ISSN :
- 1532-2661
- Volume :
- 118
- Database :
- MEDLINE
- Journal :
- Research in veterinary science
- Publication Type :
- Academic Journal
- Accession number :
- 29421486
- Full Text :
- https://doi.org/10.1016/j.rvsc.2018.01.016