Semiconducting Polymer Nanoenzymes with Photothermic Activity for Enhanced Cancer Therapy.

Authors :: Li J
Xie C
Huang J
Jiang Y
Miao Q
Pu K
Source :: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2018 Apr 03; Vol. 57 (15), pp. 3995-3998. Date of Electronic Publication: 2018 Mar 12.
Publication Year :: 2018
Abstract: Regulation of enzyme activity is fundamentally challenging but practically meaningful for biology and medicine. However, noninvasive remote control of enzyme activity in living systems has been rarely demonstrated and exploited for therapy. Herein, we synthesize a semiconducting polymer nanoenzyme with photothermic activity for enhanced cancer therapy. Upon near-infrared (NIR) light irradiation, the activity of the nanoenzyme can be enhanced by 3.5-fold to efficiently digest collagen in the tumor extracellular matrix (ECM), leading to enhanced nanoparticle accumulation in tumors and consequently improved photothermal therapy (PTT). This study thus provides a promising strategy to remotely regulate enzyme activity for cancer therapy.<br /> (© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Subjects :: Animals
Biocompatible Materials chemistry
Biocompatible Materials therapeutic use
Cell Line, Tumor
Humans
Hyperthermia, Induced
Mice
Microscopy, Confocal
Nanoparticles therapeutic use
Neoplasms therapy
Optical Imaging
Phototherapy
Semiconductors
Transplantation, Heterologous
Infrared Rays
Nanoparticles chemistry
Polymers chemistry

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