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MeCP2 as an Activator of Gene Expression.
- Source :
-
Trends in neurosciences [Trends Neurosci] 2018 Feb; Vol. 41 (2), pp. 72-74. - Publication Year :
- 2018
-
Abstract
- Rett syndrome is a neurodevelopmental disorder that primarily affects females and is caused by mutations in the methyl-CpG-binding-protein 2 (MECP2) gene. Initially, MeCP2 had been shown to be a repressor of gene transcription. In their 2008 paper, Chahrour and colleagues (DOI: 10.1126/science.1153252) reported that MeCP2 could also function as a transcriptional activator.<br /> (Copyright © 2017 Elsevier Ltd. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1878-108X
- Volume :
- 41
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Trends in neurosciences
- Publication Type :
- Academic Journal
- Accession number :
- 29405930
- Full Text :
- https://doi.org/10.1016/j.tins.2017.11.005