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Nickel(0)-Catalyzed Hydroalkenylation of Imines with Styrene and Its Derivatives.
- Source :
-
Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2018 Mar 19; Vol. 57 (13), pp. 3396-3400. Date of Electronic Publication: 2018 Feb 26. - Publication Year :
- 2018
-
Abstract
- A nickel(0)-catalyzed hydroalkenylation of imines with styrene and its derivatives is described. A wide range of aromatic and aliphatic imines directly coupled with styrene and its derivatives, thus providing various synthetically useful allylic amines with up to 95 % yield. The reaction offers a new atom- and step-economical approach to allylic amines by using alkenes instead of alkenyl-metallic reagents. Experiments and DFT calculations showed that TsNH <subscript>2</subscript> promotes the proton transfer from the coordinated olefin to the imine, accompanied by a new C-C bond formation.<br /> (© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.)
Details
- Language :
- English
- ISSN :
- 1521-3773
- Volume :
- 57
- Issue :
- 13
- Database :
- MEDLINE
- Journal :
- Angewandte Chemie (International ed. in English)
- Publication Type :
- Academic Journal
- Accession number :
- 29399987
- Full Text :
- https://doi.org/10.1002/anie.201713333