Back to Search
Start Over
Nardostachys jatamansi Ethanol Extract Ameliorates Aβ42 Cytotoxicity.
- Source :
-
Biological & pharmaceutical bulletin [Biol Pharm Bull] 2018 Apr 01; Vol. 41 (4), pp. 470-477. Date of Electronic Publication: 2018 Feb 03. - Publication Year :
- 2018
-
Abstract
- The Nardostachys jatamansi DC (NJ) root has been used as a sedative or analgesic to treat neurological symptoms and pain in traditional Korean medicine. Here, we investigate the potential effects of NJ on Alzheimer's disease (AD) and reveal the molecular mechanism through which NJ exerts its effects. The neuroprotective effect of the NJ root ethanol extract against β amyloid (Aβ) toxicity was examined in vitro using a cell culture system and in vivo using a Drosophila AD model. The NJ extract and chlorogenic acid, a major component of NJ, inhibited Aβ-induced cell death in SH-SY5Y cells. Moreover, the NJ extract rescued the neurological phenotypes of the Aβ42-expressing flies (decreased survival and pupariation rate and a locomotor defect) and suppressed Aβ42-induced cell death in the brain. We also found that NJ extract intake reduced glial cell number, reactive oxygen species level, extracellular-signal-regulated kinase (ERK) phosphorylation, and nitric oxide level in Aβ42-expressing flies, without affecting Aβ accumulation. These data suggest that the neuroprotective activity of NJ might be associated with its antioxidant and anti-inflammatory properties, as well as its inhibitory action against ERK signaling; thus, NJ is a promising medicinal plant for the development of AD treatment.
- Subjects :
- Alzheimer Disease metabolism
Alzheimer Disease pathology
Amyloid beta-Peptides antagonists & inhibitors
Amyloid beta-Peptides genetics
Amyloid beta-Peptides metabolism
Animals
Animals, Genetically Modified
Brain metabolism
Brain pathology
Cell Line
Cell Survival drug effects
Cells, Cultured
Drosophila genetics
Drosophila growth & development
Ethnopharmacology
Humans
Larva drug effects
Larva metabolism
Medicine, Korean Traditional
Nerve Tissue Proteins
Neurons metabolism
Neurons pathology
Neuroprotective Agents pharmacology
Peptide Fragments antagonists & inhibitors
Peptide Fragments genetics
Peptide Fragments metabolism
Phytotherapy
Plant Extracts pharmacology
Republic of Korea
Survival Analysis
Alzheimer Disease drug therapy
Brain drug effects
Nardostachys chemistry
Neurons drug effects
Neuroprotective Agents therapeutic use
Plant Extracts therapeutic use
Plant Roots chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1347-5215
- Volume :
- 41
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Biological & pharmaceutical bulletin
- Publication Type :
- Academic Journal
- Accession number :
- 29398668
- Full Text :
- https://doi.org/10.1248/bpb.b17-00750