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Cartilage turnover and intra-articular corticosteroid injections in knee osteoarthritis.
- Source :
-
Rheumatology international [Rheumatol Int] 2018 Mar; Vol. 38 (3), pp. 455-459. Date of Electronic Publication: 2018 Feb 02. - Publication Year :
- 2018
-
Abstract
- Intra-articular corticosteroid injections (IACI) are commonly used interventions for pain relief in patients with knee osteoarthritis (OA). Biomarkers may be helpful in further elucidating how IACI exert their effect. The aim of this study is to look at the response of biomarkers of cartilage and bone metabolism after IACI in knee OA. Eighty subjects with symptomatic knee OA [45% male, mean age (SD) 64 (11) years] underwent routine knee joint injection with 40 mg triamcinolone acetonide and 4 ml 1% lignocaine. Knee pain (as pain subscale of WOMAC VAS) and biomarkers [C-telopeptides of type-II collagen (uCTX-II), and N-telopeptides of type-I collagen in urine; cartilage oligomeric matrix protein (COMP), hyaluronic acid, N-terminal propeptide of type-IIA collagen, and human cartilage glycoprotein-39 (YKL-40) in serum] were measured at baseline and 3 weeks after IACI. Radiographic severity of disease was evaluated using knee radiographs. Median uCTX-II, a cartilage degradation marker, was lower at 3 weeks post IACI compared with baseline: 306.3 and 349.9 ng/mmol, respectively (pā<ā0.01), which remained significant after Bonferroni correction. Apart from a weak trend of lower sCOMP post IACI (pā=ā0.089), other biomarkers showed no change after IACI. Both baseline uCTX-II values and the change in uCTX-II from baseline to 3 weeks post injection correlated with radiographic severity of joint space narrowing, but not osteophyte grade. No association between uCTX-II and pain was observed. This observational study suggests that IACI in knee OA may reduce cartilage degradation in the short term.
- Subjects :
- Adrenal Cortex Hormones adverse effects
Aged
Anesthetics, Local administration & dosage
Biomarkers blood
Biomarkers urine
Bone Remodeling drug effects
Cartilage Oligomeric Matrix Protein blood
Cartilage, Articular diagnostic imaging
Cartilage, Articular metabolism
Cartilage, Articular physiopathology
Chitinase-3-Like Protein 1 blood
Collagen Type I urine
Collagen Type II urine
Female
Humans
Hyaluronic Acid blood
Injections, Intra-Articular
Knee Joint diagnostic imaging
Knee Joint metabolism
Knee Joint physiopathology
Lidocaine administration & dosage
Male
Middle Aged
Osteoarthritis, Knee diagnostic imaging
Osteoarthritis, Knee metabolism
Osteoarthritis, Knee physiopathology
Pain Measurement
Peptide Fragments blood
Peptide Fragments urine
Peptides urine
Procollagen blood
Severity of Illness Index
Time Factors
Treatment Outcome
Triamcinolone Acetonide adverse effects
Adrenal Cortex Hormones administration & dosage
Cartilage, Articular drug effects
Chondrogenesis drug effects
Knee Joint drug effects
Osteoarthritis, Knee drug therapy
Triamcinolone Acetonide administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1437-160X
- Volume :
- 38
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Rheumatology international
- Publication Type :
- Academic Journal
- Accession number :
- 29396701
- Full Text :
- https://doi.org/10.1007/s00296-018-3988-2