TLR3 expression status predicts prognosis in patients with advanced thoracic esophageal squamous cell carcinoma after esophagectomy.

Authors :: Sato Y
Motoyama S
Wakita A
Kawakita Y
Liu J
Nagaki Y
Nanjo H
Terata K
Imai K
Saito H
Minamiya Y
Source :: American journal of surgery [Am J Surg] 2018 Aug; Vol. 216 (2), pp. 319-325. Date of Electronic Publication: 2018 Feb 01.
Publication Year :: 2018
Abstract: Background: The relationship between Toll-like receptors (TLRs) and esophageal squamous cell carcinoma (ESCC) is not completely understood.<br />Methods: RT-qPCR was used to evaluate the mRNA expression of TLR1-10 in 13 ESCC lines. We then used ESCC tissue microarray (TMA) to confirm expression of TLR3 protein in patients with ESCC.<br />Results: All ESCC lines showed 10-60 times higher TLR3 mRNA expression than PBLs. High expression of TLR3 correlated with favorable 5-year overall survival (OS) and disease specific survival (DSS) among patients with ESCC after esophagectomy (p < 0.01). Additionally, In the adjuvant chemotherapy group, TLR3 high patients had significantly better 5-year OS compared to TLR3 low patients (60.2%, 34.4%, respectively) but not in the surgery alone group.<br />Conclusion: High TLR3 expression is an independent prognostic factor and has the potential to serve as a clinically useful marker of the need for adjuvant chemotherapy after esophagectomy in patients with advanced thoracic ESCC.<br /> (Copyright © 2018 Elsevier Inc. All rights reserved.)

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