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Common Variable Immunodeficiency and Gastric Malignancies.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2018 Feb 02; Vol. 19 (2). Date of Electronic Publication: 2018 Feb 02. - Publication Year :
- 2018
-
Abstract
- Common variable immunodeficiency (CVID) is an immunodeficiency disorder with a high incidence of gastrointestinal manifestations and an increased risk of gastric carcinoma and lymphoma. This review discusses the latest advancements into the immunological, clinical and diagnostic aspects of gastric malignancies in patients with CVID. The exact molecular pathways underlying the relationships between CVID and gastric malignancies remain poorly understood. These include genetics, immune dysregulation and chronic infections by Helicobacter pylori . Further studies are needed to better stratify the risk for cancer in these patients, to elaborate surveillance programs aimed at preventing these complications, and to develop new and more effective therapeutic approaches.<br />Competing Interests: The authors declare no conflict of interest.
- Subjects :
- Adenocarcinoma diagnosis
Adenocarcinoma drug therapy
Adenocarcinoma immunology
Adrenal Cortex Hormones therapeutic use
Antineoplastic Agents therapeutic use
B-Lymphocytes drug effects
B-Lymphocytes immunology
B-Lymphocytes pathology
Common Variable Immunodeficiency diagnosis
Common Variable Immunodeficiency drug therapy
Common Variable Immunodeficiency immunology
Decision Trees
Disease Management
Early Detection of Cancer
Helicobacter pylori pathogenicity
Helicobacter pylori physiology
Humans
Immunoglobulins therapeutic use
Lymphoma diagnosis
Lymphoma drug therapy
Lymphoma immunology
Stomach Neoplasms diagnosis
Stomach Neoplasms drug therapy
Stomach Neoplasms immunology
T-Lymphocytes drug effects
T-Lymphocytes immunology
T-Lymphocytes pathology
Adenocarcinoma pathology
Common Variable Immunodeficiency pathology
Immunoglobulins deficiency
Lymphoma pathology
Stomach Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 19
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 29393912
- Full Text :
- https://doi.org/10.3390/ijms19020451