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Upregulation of long non‑coding RNA CCAT2 indicates a poor prognosis and promotes proliferation and metastasis in intrahepatic cholangiocarcinoma.
- Source :
-
Molecular medicine reports [Mol Med Rep] 2018 Apr; Vol. 17 (4), pp. 5328-5335. Date of Electronic Publication: 2018 Jan 30. - Publication Year :
- 2018
-
Abstract
- Intrahepatic cholangiocarcinoma (IHCC) is an aggressive cancer with a poor survival rate and is the second most common type of primary cancer of the hepatobiliary system. At present, the molecular mechanisms of IHCC initiation and progression remain unclear. Recent evidence has indicated that long non‑coding RNAs (lncRNAs) serve a crucial role in cancer development; however, the functional role of lncRNAs in IHCC has not been investigated in detail. In the present study, a marked overexpression of lncRNA colon cancer‑associated transcript 2 (CCAT2) was observed in IHCC cell lines and clinical specimens. Statistical analysis of IHCC clinicopathological characteristics and CCAT2 expression data revealed that high CCAT2 expression levels correlated with microvascular invasion, differentiation grade, tumor (T), lymph node (N), metastasis (M) and overall TNM stages of IHCC (P<0.05). Kaplan‑Meier analysis demonstrated that CCAT2 upregulation was associated with poor overall survival and progression‑free survival in IHCC. Furthermore, high CCAT2 expression was identified as an independent risk factor of IHCC poor prognosis in both univariate and multivariate Cox regression analyses. The role of CCAT2 in promoting IHCC cell proliferation, motility and invasion was further confirmed with in vitro assays. Therefore, CCAT2 may promote IHCC progression and metastasis, and may be a promising prognostic biomarker and therapeutic target in IHCC.
- Subjects :
- Adult
Aged
Bile Duct Neoplasms pathology
Cell Line, Tumor
Cell Proliferation
Cholangiocarcinoma pathology
Disease Progression
Female
Gene Expression
Humans
Male
Middle Aged
Neoplasm Grading
Neoplasm Metastasis
Neoplasm Staging
Prognosis
ROC Curve
Bile Duct Neoplasms genetics
Bile Duct Neoplasms mortality
Cholangiocarcinoma genetics
Cholangiocarcinoma mortality
Gene Expression Regulation, Neoplastic
RNA, Long Noncoding genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1791-3004
- Volume :
- 17
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Molecular medicine reports
- Publication Type :
- Academic Journal
- Accession number :
- 29393466
- Full Text :
- https://doi.org/10.3892/mmr.2018.8518