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Clinical Course and Outcome of Childhood Acquired Platelet Dysfunction with Eosinophilia.
- Source :
-
Acta haematologica [Acta Haematol] 2018; Vol. 139 (1), pp. 28-32. Date of Electronic Publication: 2018 Jan 11. - Publication Year :
- 2018
-
Abstract
- Acquired platelet dysfunction with eosinophilia (APDE) is a syndrome which manifests as a transient state of platelet dysfunction in the presence of eosinophilia. The aim of this work was to study the clinical course and outcomes of children diagnosed with APDE. The hospital records of children with APDE were retrospectively reviewed and a total of 69 children were included. The mean (standard deviation) age at diagnosis was 6.9 (3.1) years. All of the patients presented with ecchymoses on the extremities, body, and face. None had serious bleeding symptoms. Platelet counts were within the normal range but all of the patients had abnormal platelet morphology by light microscopy. Parasitic infestation was found in 38% and most (87%) were treated with antiparasitic drugs. The median time from the onset of symptoms to remission was 2.6 months (95% CI 1.8-3.1). The overall complete remission rates at 3, 6, and 12 months were 61, 90, and 94%, respectively, with a median follow-up time after remission of 14.0 months (interquartile range 6.0-30.8). Neither univariate nor multivariate analysis indicated any statistically significant determinants for remission time. In our study, APDE was transient with spontaneous remission, no serious bleeding manifestations, and had a benign clinical course.<br /> (© 2018 S. Karger AG, Basel.)
- Subjects :
- Adolescent
Age Factors
Blood Platelet Disorders blood
Blood Platelet Disorders diagnosis
Child
Child, Preschool
Eosinophilia blood
Eosinophilia diagnosis
Female
Humans
Incidence
Infant
Infant, Newborn
Male
Platelet Function Tests
Retrospective Studies
Blood Platelet Disorders epidemiology
Eosinophilia epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1421-9662
- Volume :
- 139
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Acta haematologica
- Publication Type :
- Academic Journal
- Accession number :
- 29393084
- Full Text :
- https://doi.org/10.1159/000485790