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A Review of Combination Antimicrobial Therapy for Enterococcus faecalis Bloodstream Infections and Infective Endocarditis.
- Source :
-
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2018 Jul 02; Vol. 67 (2), pp. 303-309. - Publication Year :
- 2018
-
Abstract
- Enterococci, one of the most common causes of hospital-associated infections, are responsible for substantial morbidity and mortality. Enterococcus faecalis, the more common and virulent species, causes serious high-inoculum infections, namely infective endocarditis, that are associated with cardiac surgery and mortality rates that remained unchanged for the last 30 years. The best cures for these infections are observed with combination antibiotic therapy; however, optimal treatment has not been fully elucidated. It is the purpose of this review to highlight treatment options and their limitations, and provide direction for future investigative efforts to aid in the treatment of these severe infections. While ampicillin plus ceftriaxone has emerged as a preferred treatment option, mortality rates continue to be high, and from a safety standpoint, ceftriaxone, unlike other cephalosporins, promotes colonization with vancomycin resistant-enterococci due to high biliary concentrations. More research is needed to improve patient outcomes from this high-mortality disease.
- Subjects :
- Ampicillin therapeutic use
Ceftriaxone therapeutic use
Cephalosporins therapeutic use
Clinical Trials as Topic
Drug Synergism
Drug Therapy, Combination
Gram-Positive Bacterial Infections complications
Humans
Microbial Sensitivity Tests
Vancomycin-Resistant Enterococci drug effects
Anti-Bacterial Agents therapeutic use
Bacteremia drug therapy
Endocarditis, Bacterial drug therapy
Enterococcus faecalis drug effects
Gram-Positive Bacterial Infections drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1537-6591
- Volume :
- 67
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
- Publication Type :
- Academic Journal
- Accession number :
- 29390132
- Full Text :
- https://doi.org/10.1093/cid/ciy064