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Nitric oxide signalling in cardiovascular health and disease.
- Source :
-
Nature reviews. Cardiology [Nat Rev Cardiol] 2018 May; Vol. 15 (5), pp. 292-316. Date of Electronic Publication: 2018 Feb 01. - Publication Year :
- 2018
-
Abstract
- Nitric oxide (NO) signalling has pleiotropic roles in biology and a crucial function in cardiovascular homeostasis. Tremendous knowledge has been accumulated on the mechanisms of the nitric oxide synthase (NOS)-NO pathway, but how this highly reactive, free radical gas signals to specific targets for precise regulation of cardiovascular function remains the focus of much intense research. In this Review, we summarize the updated paradigms on NOS regulation, NO interaction with reactive oxidant species in specific subcellular compartments, and downstream effects of NO in target cardiovascular tissues, while emphasizing the latest developments of molecular tools and biomarkers to modulate and monitor NO production and bioavailability.
- Subjects :
- Adenylyl Cyclases metabolism
Adrenergic beta-3 Receptor Agonists therapeutic use
Animals
Cardiovascular Diseases drug therapy
Cardiovascular Diseases physiopathology
Cardiovascular System drug effects
Cardiovascular System physiopathology
Enzyme Activation
Enzyme Activators therapeutic use
Humans
Nitric Oxide Donors therapeutic use
Phosphodiesterase 5 Inhibitors therapeutic use
Reactive Oxygen Species metabolism
Receptors, Adrenergic, beta-3 drug effects
Receptors, Adrenergic, beta-3 metabolism
Cardiovascular Diseases metabolism
Cardiovascular System metabolism
Nitric Oxide metabolism
Nitric Oxide Synthase metabolism
Signal Transduction drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1759-5010
- Volume :
- 15
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Nature reviews. Cardiology
- Publication Type :
- Academic Journal
- Accession number :
- 29388567
- Full Text :
- https://doi.org/10.1038/nrcardio.2017.224