Effects on Sperms' Quality of Selegiline in Aged Rats.

Authors :: Kalász H
Thuróczy J
Karvaly G
Balogh L
Gyertyán I
Tóth-Molnár E
Adeghate E
Tekes K
Source :: The open medicinal chemistry journal [Open Med Chem J] 2017 Nov 30; Vol. 11, pp. 138-145. Date of Electronic Publication: 2017 Nov 30 (Print Publication: 2017).
Publication Year :: 2017
Abstract: Background: Selegiline is used to treat Parkinsonian patients. Other indications of its use have recently been discovered.<br />Objective: Scouting special and beneficial side effects of selegiline treatment.<br />Method: Two-year old male Wistar rats were daily treated with 0.25 mg/kg of selegiline s.c. (subcutaneous injection). The rats were sacrificed following a four-weeks' treatment.<br />Results: Mass of testes, number of sperms, progressive motility of sperms, and their viability definitely increased.<br />Conclusion: Selegiline can successfully be used to stop/counterbalance certain symptoms of aging.