Measurement of Human Immunodeficiency Virus p24 Antigen in Human Cerebrospinal Fluid With Digital Enzyme-Linked Immunosorbent Assay and Association With Decreased Neuropsychological Performance.

Authors :: Anderson AM
Tyor WR
Mulligan MJ
Waldrop-Valverde D
Lennox JL
Letendre SL
Source :: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2018 Jun 18; Vol. 67 (1), pp. 137-140.
Publication Year :: 2018
Abstract: New tools are needed to understand human immunodeficiency virus central nervous system involvement. Testing 15 cerebrospinal fluid (CSF) samples for p24 antigen, using a high-sensitivity assay, we found a strong correlation trend between CSF p24 concentration and worse neuropsychological performance.

Subjects :: Adult
Enzyme-Linked Immunosorbent Assay
Female
HIV Infections diagnosis
Humans
Male
Middle Aged
Neurocognitive Disorders diagnosis
Neuropsychological Tests
RNA, Viral blood
RNA, Viral cerebrospinal fluid
HIV Core Protein p24 cerebrospinal fluid
HIV Infections cerebrospinal fluid
HIV Infections complications
HIV-1 isolation & purification
Neurocognitive Disorders etiology

Language :: English
ISSN :: 1537-6591
Volume :: 67
Issue :: 1
Database :: MEDLINE
Journal :: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Publication Type :: Academic Journal
Accession number :: 29385540
Full Text :: https://doi.org/10.1093/cid/ciy056

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