Advanced Continuous Flow Platform for On-Demand Pharmaceutical Manufacturing.

Authors :: Zhang P
Weeranoppanant N
Thomas DA
Tahara K
Stelzer T
Russell MG
O'Mahony M
Myerson AS
Lin H
Kelly LP
Jensen KF
Jamison TF
Dai C
Cui Y
Briggs N
Beingessner RL
Adamo A
Source :: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2018 Feb 21; Vol. 24 (11), pp. 2776-2784. Date of Electronic Publication: 2018 Jan 31.
Publication Year :: 2018
Abstract: As a demonstration of an alternative to the challenges faced with batch pharmaceutical manufacturing including the large production footprint and lengthy time-scale, we previously reported a refrigerator-sized continuous flow system for the on-demand production of essential medicines. Building on this technology, herein we report a second-generation, reconfigurable and 25 % smaller (by volume) continuous flow pharmaceutical manufacturing platform featuring advances in reaction and purification equipment. Consisting of two compact [0.7 (L)×0.5 (D)×1.3 m (H)] stand-alone units for synthesis and purification/formulation processes, the capabilities of this automated system are demonstrated with the synthesis of nicardipine hydrochloride and the production of concentrated liquid doses of ciprofloxacin hydrochloride, neostigmine methylsulfate and rufinamide that meet US Pharmacopeia standards.<br /> (© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.)