Back to Search
Start Over
The Efficacy of Plasma Rich in Growth Factors for the Treatment of Alveolar Osteitis: A Randomized Controlled Trial.
- Source :
-
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons [J Oral Maxillofac Surg] 2018 Jun; Vol. 76 (6), pp. 1150-1159. Date of Electronic Publication: 2018 Jan 08. - Publication Year :
- 2018
-
Abstract
- Purpose: To investigate the efficacy of plasma rich in growth factors (PRGF; BTI Biotechnology Institute, San Antonio, Spain) for the treatment of alveolar osteitis compared with a positive control (Alvogyl; Septodont, Maidstone, Kent, UK).<br />Materials and Methods: This single-center, single-blinded, randomized, 2-treatment, parallel study was conducted in a UK dental hospital. All healthy adults who presented with alveolar osteitis after tooth extraction over a 3-month period were invited to participate. Each socket was randomized and treated with 1 of 2 treatment modalities, a test treatment (PRGF) or a positive control (Alvogyl). After treatment, patients were reviewed at 3 and 7 days by a second clinician blinded to the treatment given. Outcome measures included pain, exposed bone, inflammation, halitosis, dysgeusia, and quality-of-life assessment.<br />Results: Thirty-eight patients with data from 44 sockets (22 in the PRGF group and 22 in the Alvogyl group) were analyzed. The PRGF group showed significantly faster bone coverage and significantly decreased inflammation and halitosis (P < .05) compared with the control group receiving Alvogyl. There was no significant difference for pain, quality-of-life measures, or dysgeusia between groups.<br />Conclusion: PRGF predictably treated alveolar osteitis after tooth extraction compared with the conventional standard treatment of Alvogyl, which has been used for many years. PRGF could be considered an alternative treatment for alveolar osteitis and indeed appears to have considerable advantages over Alvogyl.<br /> (Copyright © 2018 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Adult
Drug Combinations
Dry Socket etiology
Dysgeusia etiology
Eugenol
Female
Halitosis etiology
Humans
Hydrocarbons, Iodinated
Male
Middle Aged
Oils, Volatile
Pain Measurement
Plasma
Quality of Life
Single-Blind Method
Tooth Extraction adverse effects
Treatment Outcome
Wound Healing drug effects
para-Aminobenzoates
Dry Socket drug therapy
Intercellular Signaling Peptides and Proteins pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1531-5053
- Volume :
- 76
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
- Publication Type :
- Academic Journal
- Accession number :
- 29382467
- Full Text :
- https://doi.org/10.1016/j.joms.2017.12.025