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An evolutionary NS1 mutation enhances Zika virus evasion of host interferon induction.

Authors :
Xia H
Luo H
Shan C
Muruato AE
Nunes BTD
Medeiros DBA
Zou J
Xie X
Giraldo MI
Vasconcelos PFC
Weaver SC
Wang T
Rajsbaum R
Shi PY
Source :
Nature communications [Nat Commun] 2018 Jan 29; Vol. 9 (1), pp. 414. Date of Electronic Publication: 2018 Jan 29.
Publication Year :
2018

Abstract

Virus-host interactions determine an infection outcome. The Asian lineage of Zika virus (ZIKV), responsible for the recent epidemics, has fixed a mutation in the NS1 gene after 2012 that enhances mosquito infection. Here we report that the same mutation confers NS1 to inhibit interferon-β induction. This mutation enables NS1 binding to TBK1 and reduces TBK1 phosphorylation. Engineering the mutation into a pre-epidemic ZIKV strain debilitates the virus for interferon-β induction; reversing the mutation in an epidemic ZIKV strain invigorates the virus for interferon-β induction; these mutational effects are lost in IRF3-knockout cells. Additionally, ZIKV NS2A, NS2B, NS4A, NS4B, and NS5 can also suppress interferon-β production through targeting distinct components of the RIG-I pathway; however, for these proteins, no antagonistic difference is observed among various ZIKV strains. Our results support the mechanism that ZIKV has accumulated mutation(s) that increases the ability to evade immune response and potentiates infection and epidemics.

Details

Language :
English
ISSN :
2041-1723
Volume :
9
Issue :
1
Database :
MEDLINE
Journal :
Nature communications
Publication Type :
Academic Journal
Accession number :
29379028
Full Text :
https://doi.org/10.1038/s41467-017-02816-2