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Potential of anti-inflammatory agents for treatment of atherosclerosis.
- Source :
-
Experimental and molecular pathology [Exp Mol Pathol] 2018 Apr; Vol. 104 (2), pp. 114-124. Date of Electronic Publication: 2018 Jan 31. - Publication Year :
- 2018
-
Abstract
- Chronic inflammation is a central pathogenic mechanism of atherosclerosis induction and progression. Vascular inflammation is associated with accelerated onset of late atherosclerosis complications. Atherosclerosis-related inflammation is mediated by a complex cocktail of pro-inflammatory cytokines, chemokines, bioactive lipids, and adhesion molecules, and blocking the key pro-atherogenic inflammatory mechanisms can be beneficial for treatment of atherosclerosis. Therapeutic agents that specifically target some of the atherosclerosis-related inflammatory mechanisms have been evaluated in preclinical and clinical studies. The most promising anti-inflammatory compounds for treatment of atherosclerosis include non-specific anti-inflammatory drugs, phospholipase inhibitors, blockers of major inflammatory cytokines, leukotrienes, adhesion molecules, and pro-inflammatory signaling pathways, such as CCL2-CCR2 axis or p38 MAPK pathway. Ongoing studies attempt evaluating therapeutic utility of these anti-inflammatory drugs for treatment of atherosclerosis. The obtained results are important for our understanding of atherosclerosis-related inflammatory mechanisms and for designing randomized controlled studies assessing the effect of specific anti-inflammatory strategies on cardiovascular outcomes.<br /> (Copyright © 2018 Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Anti-Inflammatory Agents therapeutic use
Aspirin pharmacology
Atherosclerosis metabolism
Colchicine pharmacology
Cyclooxygenase 2 Inhibitors pharmacology
Cytokines metabolism
Humans
Inflammation drug therapy
Inflammation metabolism
Leukotrienes metabolism
Methotrexate pharmacology
Phospholipase A2 Inhibitors pharmacology
Signal Transduction drug effects
Anti-Inflammatory Agents pharmacology
Atherosclerosis drug therapy
Molecular Targeted Therapy methods
Subjects
Details
- Language :
- English
- ISSN :
- 1096-0945
- Volume :
- 104
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Experimental and molecular pathology
- Publication Type :
- Academic Journal
- Accession number :
- 29378168
- Full Text :
- https://doi.org/10.1016/j.yexmp.2018.01.008