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Association of Preoperative Nutritional Status with Prognosis in Patients with Esophageal Cancer Undergoing Salvage Esophagectomy.
- Source :
-
Anticancer research [Anticancer Res] 2018 Feb; Vol. 38 (2), pp. 933-938. - Publication Year :
- 2018
-
Abstract
- Background: To investigate whether malnutrition is associated with poor prognosis of patients who undergo salvage esophagectomy. We examined the association between the preoperative prognostic nutritional index (PNI) and prognosis of patients who undergo salvage esophagectomy.<br />Patients and Methods: We conducted a single-center retrospective study and reviewed hospital patient records for tumor characteristics and patient outcomes. Univariate and multivariate survival analyses were carried out using the Cox proportional hazards regression model.<br />Results: Thirty-two patients with esophageal squamous cell carcinoma (ESCC) who underwent salvage esophagectomy between 1998 and 2015 at our Institute were included in this study. Univariate analysis revealed that clinical response (p=0.045), preoperative PNI (p<0.001), pT (p=0.024), pN (p=0.004), and residual tumors (p<0.001) were significant prognostic factor for overall survival. Multivariate analysis using age and these five variables found no independent prognostic factors. Multivariate analysis using three preoperative variables (age, clinical response, and preoperative PNI) revealed that PNI was an independent prognostic preoperative factor for overall survival (p=0.005).<br />Conclusion: Preoperative nutritional status is associated with the prognosis of patients undergoing salvage esophagectomy.<br /> (Copyright© 2018, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
- Subjects :
- Aged
Carcinoma, Squamous Cell pathology
Esophageal Neoplasms pathology
Female
Follow-Up Studies
Humans
Male
Nutrition Assessment
Nutritional Status
Preoperative Care
Prognosis
Retrospective Studies
Survival Rate
Carcinoma, Squamous Cell surgery
Esophageal Neoplasms surgery
Esophagectomy mortality
Malnutrition physiopathology
Salvage Therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1791-7530
- Volume :
- 38
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Anticancer research
- Publication Type :
- Academic Journal
- Accession number :
- 29374724
- Full Text :
- https://doi.org/10.21873/anticanres.12306