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Cardiovascular and cerebrovascular comorbidities of juvenile dermatomyositis in US children: an analysis of the National Inpatient Sample.
- Source :
-
Rheumatology (Oxford, England) [Rheumatology (Oxford)] 2018 Apr 01; Vol. 57 (4), pp. 694-702. - Publication Year :
- 2018
-
Abstract
- Objective: JDM is associated with multiple potential risk factors for cardiovascular disease, including reduced heart rate variability, systolic/diastolic cardiac dysfunction, abnormal brachial artery reactivity and metabolic syndrome. However, little is known about cardiovascular risk in JDM. We sought to examine the association between JDM and cardiovascular risk factors and disease in US children.<br />Methods: Data from the 2002-12 National Inpatient Sample was analysed, including ∼20% of all US hospitalizations (n = 14 535 620 paediatric hospitalizations).<br />Results: JDM was significantly associated with 12 of 13 comorbidities, including hypertension [survey logistic regression; crude odds ratio (95% CI): 22.25 (15.51, 31.92)], obesity [5.87 (3.44, 10.02)], uncomplicated diabetes [7.95 (4.21, 15.00)], lipid abnormalities [5.84 (2.77, 12.31)], particularly lipodystrophy [151.08 (38.24, 596.86)], peripheral and visceral atherosclerosis [10.09 (3.70, 27.56)], late effects of cerebrovascular disease [15.49 (2.37, 101.43)], personal history of transient ischaemic attack and cerebral infarction [10.82 (2.46, 47.65)], pulmonary circulatory disorder [12.23 (2.59, 57.73)], arrhythmia [3.93 (2.80, 5.52)], bradycardia [4.22 (2.65, 6.74)] and hypotension [2.62 (1.27, 5.39)].<br />Conclusions: There are significantly higher odds of cardiovascular and cerebrovascular comorbidities among inpatients with JDM, with adolescents, girls and racial/ethnic minorities being at highest risk.
- Subjects :
- Adolescent
Age Factors
Child
Child, Preschool
Comorbidity trends
Female
Humans
Infant
Infant, Newborn
Male
Odds Ratio
Retrospective Studies
Risk Factors
Sex Factors
United States epidemiology
Cardiovascular Diseases ethnology
Cerebrovascular Disorders ethnology
Dermatomyositis epidemiology
Ethnicity
Inpatients statistics & numerical data
Population Surveillance
Risk Assessment methods
Subjects
Details
- Language :
- English
- ISSN :
- 1462-0332
- Volume :
- 57
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Rheumatology (Oxford, England)
- Publication Type :
- Academic Journal
- Accession number :
- 29373707
- Full Text :
- https://doi.org/10.1093/rheumatology/kex465