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[In vitro fertilization versus conversion to intrauterine insemination in patients with poor response to controlled ovarian hyperstimulation].
- Source :
-
Gynecologie, obstetrique, fertilite & senologie [Gynecol Obstet Fertil Senol] 2018 Feb; Vol. 46 (2), pp. 118-123. Date of Electronic Publication: 2018 Jan 17. - Publication Year :
- 2018
-
Abstract
- In women undergoing controlled ovarian hyperstimulation (COH) for in vitro fertilization (IVF), a poor ovarian response, defined as three of fewer mature follicles, can lead to cancellation of the cycle. However, in women with at least one patent tube and normal semen parameters, conversion to intrauterine insemination (IUI) is considered an option, offering reasonable pregnancy rates at a lower cost and without the complications associated with oocyte retrieval. Studies have shown that in cycles with only one mature follicle, IVF should be canceled. However, in cycles with 2 or 3 mature follicles, patients have the choice between IVF and conversion to IUI. Some studies have shown that IVF is superior to IUI in such cases, whereas other reports failed to find any difference. Most of these studies are retrospective and limited by the presence of several biases and low numbers of cycles, and to this date, there is no consensus on the best approach. We have thus designed a multicenter, randomized non-inferiority study, comparing live birth rates following conversion to IUI or IVF in patients with 2 or 3 mature follicles in COH cycles. Nine hundred and forty patients will be randomized on trigger day to either IVF or conversion to IUI. Our study will also include a medico-economic analysis.<br /> (Copyright © 2017 Elsevier Masson SAS. All rights reserved.)
- Subjects :
- Adult
Costs and Cost Analysis
Female
Humans
Oocyte Retrieval adverse effects
Oocyte Retrieval economics
Ovarian Follicle anatomy & histology
Pregnancy
Randomized Controlled Trials as Topic
Treatment Outcome
Fertilization in Vitro economics
Insemination, Artificial economics
Ovulation Induction
Subjects
Details
- Language :
- French
- ISSN :
- 2468-7189
- Volume :
- 46
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Gynecologie, obstetrique, fertilite & senologie
- Publication Type :
- Academic Journal
- Accession number :
- 29373313
- Full Text :
- https://doi.org/10.1016/j.gofs.2017.11.001