7-trans-(2-Pyridylethenyl)-5H-thiazolo[3,2-a]pyrimidine-5-ones: synthesis and pharmacological activity.

Authors :: Doria G
Passarotti C
Sala R
Magrini R
Sberze P
Tibolla M
Ceserani R
Arcari G
Castello R
Toti D
Source :: Il Farmaco; edizione scientifica [Farmaco Sci] 1985 Dec; Vol. 40 (12), pp. 885-94.
Publication Year :: 1985
Abstract: A series of 7-trans-(2-pyridylethenyl)-5H-thiazolo[3,2-a]pyrimidine-5-ones was synthesized and evaluated for their pharmacological activity. Some compounds were found to be effective in inhibiting restraint ulcers in the rat. Two of them also showed interesting antiinflammatory activity.

Subjects :: Animals
Arthus Reaction prevention & control
Chemical Phenomena
Chemistry
Gastric Mucosa metabolism
Male
Parasympatholytics chemical synthesis
Pyridines pharmacology
Pyrimidinones pharmacology
Rats
Rats, Inbred Strains
Thiazoles pharmacology
Anti-Inflammatory Agents chemical synthesis
Anti-Ulcer Agents chemical synthesis
Pyridines chemical synthesis
Pyrimidinones chemical synthesis
Thiazoles chemical synthesis

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