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Erythritol Attenuates Postprandial Blood Glucose by Inhibiting α-Glucosidase.
- Source :
-
Journal of agricultural and food chemistry [J Agric Food Chem] 2018 Feb 14; Vol. 66 (6), pp. 1401-1407. Date of Electronic Publication: 2018 Feb 05. - Publication Year :
- 2018
-
Abstract
- Diabetes mellitus (DM) is a serious metabolic disorder, where impaired postprandial blood glucose regulation often leads to severe health complications. The natural chemical erythritol is a C4 polyol approved by the U.S. Food and Drug Administration for use as a sweetener. Here, we examined a potential role for erythritol in the control of postprandial blood glucose levels in DM. An anti-postprandial hyperglycemia effect upon erythritol administration (500 mg kg <superscript>-1</superscript> ) was demonstrated in alloxan-induced DM model mice by monitoring changes in blood glucose after intragastric administration of drugs and starch. We also found that erythritol most likely exerts its anti-postprandial hyperglycemic activities by inhibiting α-glucosidase in a competitive manner. This was supported by enzyme activity assays and molecular modeling experiments. In the latter experiments, it was possible to successfully dock erythritol into the catalytic pocket of α-glucosidase, with the resultant interaction likely driven by electrostatic interactions involving Asp215, Asp69, and Arg446 residues. This study suggests that erythritol may not only serve as a glucose substitute but also be a useful agent in the treatment of DM to help manage postprandial blood glucose levels.
- Subjects :
- Animals
Diabetes Mellitus, Type 2 enzymology
Diabetes Mellitus, Type 2 metabolism
Humans
Male
Mice
Postprandial Period
alpha-Glucosidases chemistry
alpha-Glucosidases metabolism
Blood Glucose metabolism
Diabetes Mellitus, Type 2 drug therapy
Erythritol administration & dosage
Glycoside Hydrolase Inhibitors administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1520-5118
- Volume :
- 66
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of agricultural and food chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 29361825
- Full Text :
- https://doi.org/10.1021/acs.jafc.7b05033