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Renal tubule injury: a driving force toward chronic kidney disease.
- Source :
-
Kidney international [Kidney Int] 2018 Mar; Vol. 93 (3), pp. 568-579. Date of Electronic Publication: 2018 Jan 17. - Publication Year :
- 2018
-
Abstract
- Renal tubules are the major component of the kidney and are vulnerable to a variety of injuries including hypoxia, proteinuria, toxins, metabolic disorders, and senescence. It has long been believed that tubules are the victim of injury. In this review, we shift this concept to renal tubules as a driving force in the progression of kidney diseases. In response to injury, tubular epithelial cells undergo changes and function as inflammatory and fibrogenic cells, with the consequent production of various bioactive molecules that drive interstitial inflammation and fibrosis. Innate immune-sensing receptors on the tubular epithelium also aggravate immune responses. Necroinflammation, an autoamplification loop between tubular cell death and interstitial inflammation, leads to the exacerbation of renal injury. Furthermore, tubular cells also play an active role in progressive renal injury via emerging mechanisms associated with a partial epithelial-mesenchymal transition, cell-cycle arrest at both G1/S and G2/M check points, and metabolic disorder. Thus, a better understanding the mechanisms by which tubular injury drives inflammation and fibrosis is necessary for the development of therapeutics to halt the progression of chronic kidney disease.<br /> (Copyright © 2017 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Acute Kidney Injury immunology
Acute Kidney Injury metabolism
Acute Kidney Injury pathology
Animals
Cell Cycle Checkpoints
Cell Cycle Proteins metabolism
Cell Proliferation
Cytokines immunology
Cytokines metabolism
Disease Progression
Energy Metabolism
Epithelial-Mesenchymal Transition
Fibrosis
Humans
Immunity, Innate
Inflammation Mediators immunology
Inflammation Mediators metabolism
Renal Insufficiency, Chronic immunology
Renal Insufficiency, Chronic metabolism
Renal Insufficiency, Chronic pathology
Signal Transduction
Acute Kidney Injury complications
Epithelial Cells immunology
Epithelial Cells metabolism
Epithelial Cells pathology
Kidney Tubules immunology
Kidney Tubules metabolism
Kidney Tubules pathology
Renal Insufficiency, Chronic etiology
Subjects
Details
- Language :
- English
- ISSN :
- 1523-1755
- Volume :
- 93
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Kidney international
- Publication Type :
- Academic Journal
- Accession number :
- 29361307
- Full Text :
- https://doi.org/10.1016/j.kint.2017.09.033