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Layered Aggregation with Steric Effect: Morphology-Homogeneous Semiconductor MoS 2 as an Alternative 2D Probe for Visual Immunoassay.

Authors :
Li BL
Peng LY
Zou HL
Li LJ
Luo HQ
Li NB
Source :
Small (Weinheim an der Bergstrasse, Germany) [Small] 2018 Feb; Vol. 14 (7). Date of Electronic Publication: 2018 Jan 22.
Publication Year :
2018

Abstract

Liquid-phase exfoliation routes unavoidably generate 2D nanostructures with inhomogeneous morphologies. Herein, thickness-dependent sorting of exfoliated nanostructures is achieved via a treatment of differential-zone centrifugation in the surfactant aqueous phase. With this approach, homogeneous MoS <subscript>2</subscript> nanosheets are obtained, and due to the intrinsic semiconducting characteristics, those 2D nanosheets are endowed with desired optical properties, rivaling classic gold nanoparticles in sensing applications. Furthermore, MoS <subscript>2</subscript> nanosheets with high uniformity and chemical inertness are coupled with proteins, exhibiting high performance in stability and anti-interferences for bioanalysis. As a consequence of aggregation-induced steric effect, distinguishing running shifts of antibody-anchored conjugates in gel electrophoresis are visually responsive to those specific antigens. This assay enables the easy and fast monitoring of tumor biomarkers just according to "naked-eye" identification of band location in electrophoresis results, which are presented by an alternative visual probe of 2D MoS <subscript>2</subscript> -protein conjugates. The developed visual immunoassay with the synergistic effect of gel electrophoresis techniques and 2D semiconductors pushes significant progress in "home-made" tests for disease early diagnosis.<br /> (© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Details

Language :
English
ISSN :
1613-6829
Volume :
14
Issue :
7
Database :
MEDLINE
Journal :
Small (Weinheim an der Bergstrasse, Germany)
Publication Type :
Academic Journal
Accession number :
29356323
Full Text :
https://doi.org/10.1002/smll.201703560