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Molybdenum cluster loaded PLGA nanoparticles: An innovative theranostic approach for the treatment of ovarian cancer.
- Source :
-
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V [Eur J Pharm Biopharm] 2018 Apr; Vol. 125, pp. 95-105. Date of Electronic Publication: 2018 Jan 31. - Publication Year :
- 2018
-
Abstract
- We evaluate poly (d,l-lactide-co-glycolide) (PLGA) nanoparticles embedding inorganic molybdenum octahedral cluster for photodynamic therapy of cancer (PDT). Tetrabutyl ammonium salt of Mo <subscript>6</subscript> Br <subscript>14</subscript> cluster unit, (TBA) <subscript>2</subscript> Mo <subscript>6</subscript> Br <subscript>14</subscript> , presents promising photosensitization activity in the destruction of targeted cancer cells. Stable cluster loaded nanoparticles (CNPs) were prepared by solvent displacement method showing spherical shapes, zeta potential values around -30 mV, polydispersity index lower than 0.2 and sizes around 100 nm. FT-IR and DSC analysis revealed the lack of strong chemical interaction between the cluster and the polymer within the nanoparticles. In vitro release study showed that (TBA) <subscript>2</subscript> Mo <subscript>6</subscript> Br <subscript>14</subscript> was totally dissolved in 20 min, while CNPs were able to control the release of encapsulated cluster. In vitro cellular viability studies conducted on A2780 ovarian cancer cell line treated up to 72 h with cluster or CNPs did not show any sign of toxicity in concentrations up to 20 µg/ml. This concentration was selected for photo-activation test on A2780 cells and CNPs were able to generate oxygen singlet resulting in a decrease of the cellular viability up to 50%, respectively compared to non-activated conditions. This work presents (TBA) <subscript>2</subscript> Mo <subscript>6</subscript> Br <subscript>14</subscript> as a novel photosensitizer for PDT and suggests PLGA nanoparticles as an efficient delivery system intended for tumor targeting.<br /> (Copyright © 2018 Elsevier B.V. All rights reserved.)
- Subjects :
- Cell Line, Tumor
Cell Survival drug effects
Cell Survival physiology
Drug Carriers administration & dosage
Drug Carriers metabolism
Female
Humans
Lactic Acid administration & dosage
Lactic Acid metabolism
Molybdenum administration & dosage
Molybdenum metabolism
Nanoparticles administration & dosage
Nanoparticles metabolism
Particle Size
Polyglycolic Acid administration & dosage
Polyglycolic Acid metabolism
Polylactic Acid-Polyglycolic Acid Copolymer
Drug Carriers chemistry
Lactic Acid chemistry
Molybdenum chemistry
Nanoparticles chemistry
Ovarian Neoplasms drug therapy
Ovarian Neoplasms metabolism
Polyglycolic Acid chemistry
Theranostic Nanomedicine methods
Subjects
Details
- Language :
- English
- ISSN :
- 1873-3441
- Volume :
- 125
- Database :
- MEDLINE
- Journal :
- European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
- Publication Type :
- Academic Journal
- Accession number :
- 29355686
- Full Text :
- https://doi.org/10.1016/j.ejpb.2018.01.007