Dipeptidyl peptidase IV, which probably plays important roles in Alzheimer disease (AD) pathology, is upregulated in AD brain neurons and associates with amyloid plaques.

Authors :: Bernstein HG
Dobrowolny H
Keilhoff G
Steiner J
Source :: Neurochemistry international [Neurochem Int] 2018 Mar; Vol. 114, pp. 55-57. Date of Electronic Publication: 2018 Jan 17.
Publication Year :: 2018
Abstract: There is evidence from in vitro experiments that dipeptidyl peptidase IV (DPP IV) might play role(s) in amyloid formation. However, nothing is known about the localization of the enzyme in brains of individuals with Alzheimer's disease. We herein show that in comparison to non-demented controls DPP IV is upregulated in AD brain neurons and occurs in multiple amyloid plaques.<br /> (Copyright © 2018 Elsevier Ltd. All rights reserved.)

Subjects :: Alzheimer Disease drug therapy
Animals
Brain drug effects
Dipeptidyl-Peptidase IV Inhibitors pharmacology
Dipeptidyl-Peptidase IV Inhibitors therapeutic use
Humans
Neurons drug effects
Plaque, Amyloid drug therapy
Up-Regulation drug effects
Alzheimer Disease enzymology
Brain enzymology
Dipeptidyl Peptidase 4 biosynthesis
Neurons enzymology
Plaque, Amyloid enzymology
Up-Regulation physiology

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