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Metabolic reprogramming in the pathogenesis of chronic lung diseases, including BPD, COPD, and pulmonary fibrosis.
- Source :
-
American journal of physiology. Lung cellular and molecular physiology [Am J Physiol Lung Cell Mol Physiol] 2018 Apr 01; Vol. 314 (4), pp. L544-L554. Date of Electronic Publication: 2018 Jan 04. - Publication Year :
- 2018
-
Abstract
- The metabolism of nutrient substrates, including glucose, glutamine, and fatty acids, provides acetyl-CoA for the tricarboxylic acid cycle to generate energy, as well as metabolites for the biosynthesis of biomolecules, including nucleotides, proteins, and lipids. It has been shown that metabolism of glucose, fatty acid, and glutamine plays important roles in modulating cellular proliferation, differentiation, apoptosis, autophagy, senescence, and inflammatory responses. All of these cellular processes contribute to the pathogenesis of chronic lung diseases, including bronchopulmonary dysplasia, chronic obstructive pulmonary disease, and pulmonary fibrosis. Recent studies demonstrate that metabolic reprogramming occurs in patients with and animal models of chronic lung diseases, suggesting that metabolic dysregulation may participate in the pathogenesis and progression of these diseases. In this review, we briefly discuss the catabolic pathways for glucose, glutamine, and fatty acids, and focus on how metabolic reprogramming of these pathways impacts cellular functions and leads to the development of these chronic lung diseases. We also highlight how targeting metabolic pathways can be utilized in the prevention and treatment of these diseases.
- Subjects :
- Animals
Bronchopulmonary Dysplasia etiology
Bronchopulmonary Dysplasia metabolism
Humans
Pulmonary Disease, Chronic Obstructive etiology
Pulmonary Disease, Chronic Obstructive metabolism
Pulmonary Fibrosis etiology
Pulmonary Fibrosis metabolism
Bronchopulmonary Dysplasia pathology
Cellular Reprogramming
Metabolic Diseases complications
Pulmonary Disease, Chronic Obstructive pathology
Pulmonary Fibrosis pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1522-1504
- Volume :
- 314
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- American journal of physiology. Lung cellular and molecular physiology
- Publication Type :
- Academic Journal
- Accession number :
- 29351437
- Full Text :
- https://doi.org/10.1152/ajplung.00521.2017