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First experimental proof of Proton Boron Capture Therapy (PBCT) to enhance protontherapy effectiveness.
- Source :
-
Scientific reports [Sci Rep] 2018 Jan 18; Vol. 8 (1), pp. 1141. Date of Electronic Publication: 2018 Jan 18. - Publication Year :
- 2018
-
Abstract
- Protontherapy is hadrontherapy's fastest-growing modality and a pillar in the battle against cancer. Hadrontherapy's superiority lies in its inverted depth-dose profile, hence tumour-confined irradiation. Protons, however, lack distinct radiobiological advantages over photons or electrons. Higher LET (Linear Energy Transfer) <superscript>12</superscript> C-ions can overcome cancer radioresistance: DNA lesion complexity increases with LET, resulting in efficient cell killing, i.e. higher Relative Biological Effectiveness (RBE). However, economic and radiobiological issues hamper <superscript>12</superscript> C-ion clinical amenability. Thus, enhancing proton RBE is desirable. To this end, we exploited the p + <superscript>11</superscript> B → 3α reaction to generate high-LET alpha particles with a clinical proton beam. To maximize the reaction rate, we used sodium borocaptate (BSH) with natural boron content. Boron-Neutron Capture Therapy (BNCT) uses <superscript>10</superscript> B-enriched BSH for neutron irradiation-triggered alpha particles. We recorded significantly increased cellular lethality and chromosome aberration complexity. A strategy combining protontherapy's ballistic precision with the higher RBE promised by BNCT and <superscript>12</superscript> C-ion therapy is thus demonstrated.
- Subjects :
- Alpha Particles therapeutic use
Animals
Borohydrides chemistry
Boron chemistry
Boron Neutron Capture Therapy instrumentation
Carbon Isotopes chemistry
Cell Death radiation effects
Cell Line, Tumor
Chromosome Aberrations radiation effects
Combined Modality Therapy instrumentation
Cyclotrons
DNA Damage
DNA, Neoplasm genetics
DNA, Neoplasm metabolism
DNA, Neoplasm radiation effects
Dose-Response Relationship, Radiation
Fluorescent Dyes chemistry
Humans
Karyotyping
Linear Energy Transfer
Male
Prostatic Neoplasms pathology
Relative Biological Effectiveness
Sulfhydryl Compounds chemistry
Boron therapeutic use
Boron Neutron Capture Therapy methods
Combined Modality Therapy methods
Neutrons
Prostatic Neoplasms radiotherapy
Proton Therapy instrumentation
Proton Therapy methods
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 8
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 29348437
- Full Text :
- https://doi.org/10.1038/s41598-018-19258-5