Back to Search
Start Over
Cu I and Cu II complexes with phosphine derivatives of fluoroquinolone antibiotics - A comparative study on the cytotoxic mode of action.
- Source :
-
Journal of inorganic biochemistry [J Inorg Biochem] 2018 Apr; Vol. 181, pp. 1-10. Date of Electronic Publication: 2018 Jan 09. - Publication Year :
- 2018
-
Abstract
- In this paper, we present a comparative study on the cytotoxic mode of action of copper(I) and copper(II) complexes with phosphine derivatives of fluoroquinolone antibiotics (ciprofloxacin HCp and norfloxacin HNr). The in vitro cytotoxic activity of four new compounds was tested against two selected cancer cell lines. All complexes exhibited much better cytotoxicity against both cell lines than unmodified fluoroquinolone antibiotics, their phosphines (PCp, PNr), chalcogenide derivatives (oxides: OPCp, OPNr; sulfides: SPCp, SPNr and selenides: SePCp, SePNr) and previously described by us complexes with phosphines derived from different fluoroquinolones: lomefloxacin (HLm) and sparfloxacin (HSf) as well as cisplatin. Apoptosis, observed at a great predominance, was induced by all studied complexes. Importantly, it was concluded that coordination compounds with Cu(I) ion ([Cu <superscript>I</superscript> -PNr] and [Cu <superscript>I</superscript> -PCp]) were much more active than those with Cu(II) ion ([OPNr-Cu <superscript>II</superscript> ], [OPCp-Cu <superscript>II</superscript> ]), even though the highest efficacy to produce reactive oxygen species, participating in overall cytotoxicity, was proved for copper(II) complexes among all studied compounds. Herein, we discuss not only results obtained for copper(I)/(II) complexes with phosphines derived from HNr and HCp but we also compare them to previously described data for complexes with HLm and HSf derivatives. This is the first insight into a structure-activity relationship of copper complexes with phosphine derivatives of fluoroquinolone antibiotics.<br /> (Copyright © 2018 Elsevier Inc. All rights reserved.)
- Subjects :
- Adenocarcinoma metabolism
Adenocarcinoma pathology
Adenocarcinoma of Lung
Animals
Anti-Bacterial Agents chemistry
Anti-Bacterial Agents pharmacology
Antineoplastic Agents chemistry
Apoptosis drug effects
Carcinoma drug therapy
Carcinoma metabolism
Carcinoma pathology
Cell Line, Tumor
Cell Survival drug effects
Chelating Agents chemistry
Chelating Agents pharmacology
Ciprofloxacin chemistry
Ciprofloxacin pharmacology
Colonic Neoplasms metabolism
Colonic Neoplasms pathology
Coordination Complexes chemistry
Coordination Complexes pharmacology
Copper chemistry
Electrochemical Techniques
Humans
Lung Neoplasms metabolism
Lung Neoplasms pathology
Mice
Molecular Structure
Norfloxacin chemistry
Norfloxacin pharmacology
Phosphines chemistry
Reactive Oxygen Species agonists
Reactive Oxygen Species metabolism
Structure-Activity Relationship
Adenocarcinoma drug therapy
Antineoplastic Agents pharmacology
Ciprofloxacin analogs & derivatives
Colonic Neoplasms drug therapy
Copper pharmacology
Lung Neoplasms drug therapy
Norfloxacin analogs & derivatives
Phosphines pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1873-3344
- Volume :
- 181
- Database :
- MEDLINE
- Journal :
- Journal of inorganic biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 29348049
- Full Text :
- https://doi.org/10.1016/j.jinorgbio.2018.01.008