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Analysis of experience-regulated transcriptome and imprintome during critical periods of mouse visual system development reveals spatiotemporal dynamics.
- Source :
-
Human molecular genetics [Hum Mol Genet] 2018 Mar 15; Vol. 27 (6), pp. 1039-1054. - Publication Year :
- 2018
-
Abstract
- Visual system development is light-experience dependent, which strongly implicates epigenetic mechanisms in light-regulated maturation. Among many epigenetic processes, genomic imprinting is an epigenetic mechanism through which monoallelic gene expression occurs in a parent-of-origin-specific manner. It is unknown if genomic imprinting contributes to visual system development. We profiled the transcriptome and imprintome during critical periods of mouse visual system development under normal- and dark-rearing conditions using B6/CAST F1 hybrid mice. We identified experience-regulated, isoform-specific and brain-region-specific imprinted genes. We also found imprinted microRNAs were predominantly clustered into the Dlk1-Dio3 imprinted locus with light experience affecting some imprinted miRNA expression. Our findings provide the first comprehensive analysis of light-experience regulation of the transcriptome and imprintome during critical periods of visual system development. Our results may contribute to therapeutic strategies for visual impairments and circadian rhythm disorders resulting from a dysfunctional imprintome.
- Subjects :
- Animals
DNA Methylation
Epigenesis, Genetic genetics
Gene Expression Profiling
Genomic Imprinting
Mice
Mice, Inbred Strains embryology
Mice, Inbred Strains genetics
MicroRNAs genetics
Ocular Physiological Phenomena genetics
Spatio-Temporal Analysis
Superior Colliculi embryology
Transcriptome
Adaptation, Ocular genetics
Eye embryology
Subjects
Details
- Language :
- English
- ISSN :
- 1460-2083
- Volume :
- 27
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Human molecular genetics
- Publication Type :
- Academic Journal
- Accession number :
- 29346572
- Full Text :
- https://doi.org/10.1093/hmg/ddy023