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Joint effects of chlorpyrifos and mancozeb on the terrestrial isopod Porcellionides pruinosus: A multiple biomarker approach.
- Source :
-
Environmental toxicology and chemistry [Environ Toxicol Chem] 2018 May; Vol. 37 (5), pp. 1446-1457. Date of Electronic Publication: 2018 Apr 06. - Publication Year :
- 2018
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Abstract
- The exposure to pesticides by nontarget soil biota has long been regarded as a serious downside of modern agricultural regimes and the subject of heated debate. Of utmost relevance is the exposure to pesticide mixtures because their effects have been shown to not necessarily reflect the individual toxicity of their components, and even the simple addition of effects may lead to consequences not clearly anticipated. In the present study, a multiple biomarker approach was employed to identify the mechanistic and time effects underlying several single and mixture treatments of chlorpyrifos (CPF) and mancozeb (MCZ) in juveniles and adults of the terrestrial isopod Porcellionides pruinosus. The effects of the individual pesticides and the mixtures at recommended doses were mostly transitory under these controlled conditions and one-pulse exposure. Whereas imbalances were identified on detoxification and oxidative stress-related enzymes, the isopods generally showed the ability to recover through the end of the experiment. However, juveniles displayed greater vulnerability than adults. Most of the differences between life stages occurred in energy-related parameters where distinct performances and stress-handling behaviors were observed, suggesting higher metabolic costs to juveniles. Our results stress that understanding the time dependence of the underlying mechanisms governing the joint effects of the pesticides can help in assessing and anticipating the effects of the pesticide mixtures. Moreover, we emphasize the importance of taking life stage-related differences into consideration when evaluating the environmental risks of pesticides and pesticide mixtures. Environ Toxicol Chem 2018;37:1446-1457. © 2018 SETAC.<br /> (© 2018 SETAC.)
- Subjects :
- Acetylcholinesterase metabolism
Animals
Catalase metabolism
Energy Metabolism drug effects
Glutathione Transferase metabolism
Inactivation, Metabolic drug effects
Isopoda growth & development
Life Cycle Stages drug effects
Oxidative Stress drug effects
Pesticides toxicity
Biomarkers metabolism
Chlorpyrifos toxicity
Isopoda drug effects
Maneb toxicity
Zineb toxicity
Subjects
Details
- Language :
- English
- ISSN :
- 1552-8618
- Volume :
- 37
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Environmental toxicology and chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 29336492
- Full Text :
- https://doi.org/10.1002/etc.4089