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PET attenuation correction for rigid MR Tx/Rx coils from 176 Lu background activity.

Authors :
Lerche CW
Kaltsas T
Caldeira L
Scheins J
Rota Kops E
Tellmann L
Pietrzyk U
Herzog H
Shah NJ
Source :
Physics in medicine and biology [Phys Med Biol] 2018 Feb 06; Vol. 63 (3), pp. 035039. Date of Electronic Publication: 2018 Feb 06.
Publication Year :
2018

Abstract

One challenge for PET-MR hybrid imaging is the correction for attenuation of the 511 keV annihilation radiation by the required RF transmit and/or RF receive coils. Although there are strategies for building PET transparent Tx/Rx coils, such optimised coils still cause significant attenuation of the annihilation radiation leading to artefacts and biases in the reconstructed activity concentrations. We present a straightforward method to measure the attenuation of Tx/Rx coils in simultaneous MR-PET imaging based on the natural <superscript>176</superscript> Lu background contained in the scintillator of the PET detector without the requirement of an external CT scanner or PET scanner with transmission source. The method was evaluated on a prototype 3T MR-BrainPET produced by Siemens Healthcare GmbH, both with phantom studies and with true emission images from patient/volunteer examinations. Furthermore, the count rate stability of the PET scanner and the x-ray properties of the Tx/Rx head coil were investigated. Even without energy extrapolation from the two dominant γ energies of <superscript>176</superscript> Lu to 511 keV, the presented method for attenuation correction, based on the measurement of <superscript>176</superscript> Lu background attenuation, shows slightly better performance than the coil attenuation correction currently used. The coil attenuation correction currently used is based on an external transmission scan with rotating <superscript>68</superscript> Ge sources acquired on a Siemens ECAT HR  +  PET scanner. However, the main advantage of the presented approach is its straightforwardness and ready availability without the need for additional accessories.

Details

Language :
English
ISSN :
1361-6560
Volume :
63
Issue :
3
Database :
MEDLINE
Journal :
Physics in medicine and biology
Publication Type :
Academic Journal
Accession number :
29328049
Full Text :
https://doi.org/10.1088/1361-6560/aaa72a