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Small molecule immuno-oncology therapeutic agents.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2018 Feb 01; Vol. 28 (3), pp. 319-329. Date of Electronic Publication: 2017 Dec 20. - Publication Year :
- 2018
-
Abstract
- Treatment of cancer by activation of an antitumor immune response is now a widely practiced and well-accepted approach to therapy. However, despite dramatic responses in some patients, the high proportion of unresponsive patients points to a considerable unmet medical need. Although antibody therapies have led the way, small molecule immuno-oncology agents are close behind. This perspective provides an overview of some of the many small molecule approaches being explored. It encompasses small molecule modulators of validated targets such as programed cell death 1 (PD-1) as well as novel approaches still to be proven clinically.<br /> (Copyright © 2017 Elsevier Ltd. All rights reserved.)
- Subjects :
- Animals
Antineoplastic Agents chemistry
Apoptosis drug effects
Cell Cycle Checkpoints drug effects
Cell Proliferation drug effects
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Humans
Immunologic Factors chemistry
Mice
Molecular Structure
Programmed Cell Death 1 Receptor antagonists & inhibitors
Programmed Cell Death 1 Receptor metabolism
Small Molecule Libraries chemistry
Structure-Activity Relationship
Antineoplastic Agents pharmacology
Immunologic Factors pharmacology
Small Molecule Libraries pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1464-3405
- Volume :
- 28
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 29326017
- Full Text :
- https://doi.org/10.1016/j.bmcl.2017.12.044