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Antibacterial activity of trimetal (CuZnFe) oxide nanoparticles.
- Source :
-
International journal of nanomedicine [Int J Nanomedicine] 2017 Dec 20; Vol. 13, pp. 77-87. Date of Electronic Publication: 2017 Dec 20 (Print Publication: 2018). - Publication Year :
- 2017
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Abstract
- Background: The increasing resistance of pathogenic bacteria to antibiotics is a challenging worldwide health problem that has led to the search for new and more efficient antibacterial agents. Nanotechnology has proven to be an effective tool for the fight against bacteria.<br />Methods: In this paper, we present the synthesis and traits of trimetal (CuZnFe) oxide nanoparticles (NPs) using X-ray diffraction, high-resolution transmission electron microscopy, and energy dispersive x-ray spectroscopy. We evaluated the antibacterial activity of these NPs against gram-negative Escherichia coli and gram-positive Enterococcus faecalis and then compared it to that of their pure single-metal oxide components CuO and ZnO.<br />Results: Our study showed that the antibacterial activity of the trimetal oxide NPs was greater against E . coli than against E . faecalis . Overall, the antimicrobial effect of trimetal NPs is between those of pure ZnO and CuO nanoparticles, which may mean that their cytotoxicity is also between that of pure ZnO and CuO NPs, making them potential antibiotics. However, the cytotoxicity of trimetal NPs to mammalian cells needs to be verified.<br />Conclusion: The combination of three metal oxide NPs (ZnO, CuO, and Fe <subscript>2</subscript> O <subscript>3</subscript> ) in one multimetal (CuZnFe) oxide NPs will enhance the therapeutic strategy against a wide range of microbial infections. Bacteria are unlikely to develop resistance against this new NP because bacteria must go through a series of mutations to become resistant to the trimetal oxide NP. Therefore, this NP can combat existing and emerging bacterial infections.<br />Competing Interests: Disclosure The authors report no conflicts of interest in this work.
- Subjects :
- Copper chemistry
Drug Evaluation, Preclinical methods
Drug Stability
Enterococcus faecalis drug effects
Escherichia coli drug effects
Ferric Compounds chemistry
Ferric Compounds pharmacology
Microscopy, Electron, Transmission
Nanotechnology methods
X-Ray Diffraction
Zinc Oxide chemistry
Anti-Bacterial Agents chemistry
Anti-Bacterial Agents pharmacology
Copper pharmacology
Metal Nanoparticles chemistry
Zinc Oxide pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1178-2013
- Volume :
- 13
- Database :
- MEDLINE
- Journal :
- International journal of nanomedicine
- Publication Type :
- Academic Journal
- Accession number :
- 29317817
- Full Text :
- https://doi.org/10.2147/IJN.S154218