Back to Search
Start Over
Prostatectomy-based validation of combined urine and plasma test for predicting high grade prostate cancer.
- Source :
-
The Prostate [Prostate] 2018 Mar; Vol. 78 (4), pp. 294-299. Date of Electronic Publication: 2018 Jan 08. - Publication Year :
- 2018
-
Abstract
- Background: Distinguishing between low- and high-grade prostate cancers (PCa) is important, but biopsy may underestimate the actual grade of cancer. We have previously shown that urine/plasma-based prostate-specific biomarkers can predict high grade PCa. Our objective was to determine the accuracy of a test using cell-free RNA levels of biomarkers in predicting prostatectomy results.<br />Methods: This multicenter community-based prospective study was conducted using urine/blood samples collected from 306 patients. All recruited patients were treatment-naïve, without metastases, and had been biopsied, designated a Gleason Score (GS) based on biopsy, and assigned to prostatectomy prior to participation in the study. The primary outcome measure was the urine/plasma test accuracy in predicting high grade PCa on prostatectomy compared with biopsy findings. Sensitivity and specificity were calculated using standard formulas, while comparisons between groups were performed using the Wilcoxon Rank Sum, Kruskal-Wallis, Chi-Square, and Fisher's exact test.<br />Results: GS as assigned by standard 10-12 core biopsies was 3 + 3 in 90 (29.4%), 3 + 4 in 122 (39.8%), 4 + 3 in 50 (16.3%), and > 4 + 3 in 44 (14.4%) patients. The urine/plasma assay confirmed a previous validation and was highly accurate in predicting the presence of high-grade PCa (Gleason ≥3 + 4) with sensitivity between 88% and 95% as verified by prostatectomy findings. GS was upgraded after prostatectomy in 27% of patients and downgraded in 12% of patients.<br />Conclusions: This plasma/urine biomarker test accurately predicts high grade cancer as determined by prostatectomy with a sensitivity at 92-97%, while the sensitivity of core biopsies was 78%.<br /> (© 2018 Wiley Periodicals, Inc.)
- Subjects :
- Adult
Aged
Humans
Male
Middle Aged
Neoplasm Grading
Prospective Studies
Prostate pathology
Prostate surgery
Prostatectomy methods
Prostatic Neoplasms metabolism
Prostatic Neoplasms surgery
Real-Time Polymerase Chain Reaction
Sensitivity and Specificity
Biomarkers, Tumor metabolism
Cell-Free Nucleic Acids metabolism
Prostatic Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1097-0045
- Volume :
- 78
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- The Prostate
- Publication Type :
- Academic Journal
- Accession number :
- 29315679
- Full Text :
- https://doi.org/10.1002/pros.23473