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Protuboxepin C and protuboxepin D from the sponge-derived fungus Aspergillus sp SCSIO XWS02F40.
- Source :
-
Natural product research [Nat Prod Res] 2018 Nov; Vol. 32 (21), pp. 2510-2515. Date of Electronic Publication: 2018 Jan 09. - Publication Year :
- 2018
-
Abstract
- Two new diketopiperazine alkaloids, named protuboxepin C (1) and protuboxepin D (2), which contain D-Phe residue and oxepin ring, were isolated from EtOAc extract of sponge-derived fungus Aspergillus sp SCSIO XWS02F40. Their structures were elucidated by 1D, 2D NMR and HRESIMS dates, and their absolute configurations were confirmed by single crystal X-ray diffraction experiments and CD analyses. The in vitro cytotoxicity of these two new compounds was further evaluated using A549 and Hela cell lines.
- Subjects :
- A549 Cells
Alkaloids isolation & purification
Animals
Crystallography, X-Ray
Diketopiperazines isolation & purification
HeLa Cells
Humans
Magnetic Resonance Spectroscopy
Molecular Structure
Piperazines isolation & purification
Porifera microbiology
Alkaloids chemistry
Aspergillus chemistry
Diketopiperazines chemistry
Piperazines chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1478-6427
- Volume :
- 32
- Issue :
- 21
- Database :
- MEDLINE
- Journal :
- Natural product research
- Publication Type :
- Academic Journal
- Accession number :
- 29313378
- Full Text :
- https://doi.org/10.1080/14786419.2017.1423303