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Changes of Circulating MicroRNAs in Response to Treatment With Teriparatide or Denosumab in Postmenopausal Osteoporosis.
- Source :
-
The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2018 Mar 01; Vol. 103 (3), pp. 1206-1213. - Publication Year :
- 2018
-
Abstract
- Context: Expression of microRNAs (miRs) related to bone metabolism in the serum may be affected by antiosteoporotic treatment.<br />Objective: To investigate the effect of two antiosteoporotic agents with opposite effects on bone metabolism on miR expression profile in the serum.<br />Design: Observational, open label, nonrandomized clinical trial.<br />Setting: The outpatient clinics for Metabolic Bone Diseases of 424 General Military Hospital, Thessaloniki, Greece.<br />Patients and Interventions: Postmenopausal women with low bone mass were treated with either teriparatide (TPTD; n = 30) or denosumab (n = 30) for 12 months.<br />Main Outcome Measures: Changes in the serum expression of selected miRs linked to bone metabolism at 3 and 12 months of treatment. Secondary measurements: associations of measured miRs with changes in bone mineral density (BMD) at 12 months and the bone turnover markers (BTMs) C-terminal cross-linking telopeptide of type I collagen and procollagen type I N-terminal propeptide at 3 and 12 months.<br />Results: We found significantly decreased relative expression of miR-33-3p at 3 months (P = 0.03) and of miR-133a at 12 months (P = 0.042) of TPTD treatment. BMD values at 12 months of TPTD treatment were significantly and inversely correlated with miR-124-3p expression at 3 months (P = 0.008). Relative expression of miR-24-3p and miR-27a was correlated with changes in BTMs during TPTD treatment and of miR-21-5p, miR-23a-3p, miR-26a-5p, miR-27a, miR-222-5p, and miR-335-5p with changes in BTMs during denosumab treatment.<br />Conclusions: Circulating miRs are differentially affected by treatment with TPTD and denosumab. TPTD affects the relative expression of miRs related to the expression of RUNX-2 (miR-33) and DKK-1 gene (miR-133).
- Subjects :
- Aged
Aged, 80 and over
Biomarkers blood
Bone Density drug effects
Bone Remodeling drug effects
Collagen Type I blood
Core Binding Factor Alpha 1 Subunit blood
Female
Humans
Intercellular Signaling Peptides and Proteins blood
Middle Aged
Osteoporosis, Postmenopausal blood
Peptide Fragments blood
Peptides blood
Procollagen blood
Treatment Outcome
Bone Density Conservation Agents administration & dosage
Circulating MicroRNA drug effects
Denosumab administration & dosage
Osteoporosis, Postmenopausal drug therapy
Teriparatide administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1945-7197
- Volume :
- 103
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The Journal of clinical endocrinology and metabolism
- Publication Type :
- Academic Journal
- Accession number :
- 29309589
- Full Text :
- https://doi.org/10.1210/jc.2017-02406