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Optical coherence tomography angiography indicates associations of the retinal vascular network and disease activity in multiple sclerosis.
- Source :
-
Multiple sclerosis (Houndmills, Basingstoke, England) [Mult Scler] 2019 Feb; Vol. 25 (2), pp. 224-234. Date of Electronic Publication: 2018 Jan 05. - Publication Year :
- 2019
-
Abstract
- Background: Patients with multiple sclerosis (MS) and clinically isolated syndrome (CIS) may show alterations of retinal layer architecture as measured by optical coherence tomography. Little is known about changes in the retinal vascular network during MS.<br />Objective: To characterize retinal vessel structures in patients with MS and CIS and to test for associations with MS disease activity.<br />Method: In all, 42 patients with MS or CIS and 50 healthy controls underwent retinal optical coherence tomography angiography (OCT-A) with analysis of the superficial and deep vascular plexuses and the choriocapillaries. We tested OCT-A parameters for associations with retinal layer volumes, history of optic neuritis (ON), and the retrospective disease activity.<br />Results: Inner retinal layer volumes correlated positively with the density of both the superficial and deep vascular plexuses. Eyes of MS/CIS patients with a history of ON revealed reduced vessel densities of the superficial and deep vascular plexuses as compared to healthy controls. Higher choriocapillary vessel densities were associated with ongoing inflammatory disease activity during 24 months prior to OCT-A examination in MS and CIS patients.<br />Conclusion: Optic neuritis is associated with rarefaction of the superficial and deep retinal vessels. Alterations of the choriocapillaries might be linked to disease activity in MS.
- Subjects :
- Adult
Cerebral Angiography methods
Demyelinating Diseases diagnostic imaging
Demyelinating Diseases pathology
Female
Humans
Male
Middle Aged
Multiple Sclerosis, Relapsing-Remitting diagnostic imaging
Optic Neuritis diagnostic imaging
Retina diagnostic imaging
Retina pathology
Retinal Vessels diagnostic imaging
Retrospective Studies
Tomography, Optical Coherence methods
Multiple Sclerosis, Relapsing-Remitting pathology
Optic Neuritis pathology
Retinal Vessels pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1477-0970
- Volume :
- 25
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Multiple sclerosis (Houndmills, Basingstoke, England)
- Publication Type :
- Academic Journal
- Accession number :
- 29303033
- Full Text :
- https://doi.org/10.1177/1352458517750009