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An experimental study and finite element modeling of head and neck cooling for brain hypothermia.
- Source :
-
Journal of thermal biology [J Therm Biol] 2018 Jan; Vol. 71, pp. 99-111. Date of Electronic Publication: 2017 Nov 04. - Publication Year :
- 2018
-
Abstract
- Reducing brain temperature by head and neck cooling is likely to be the protective treatment for humans when subjects to sudden cardiac arrest. This study develops the experimental validation model and finite element modeling (FEM) to study the head and neck cooling separately, which can induce therapeutic hypothermia focused on the brain. Anatomically accurate geometries based on CT images of the skull and carotid artery are utilized to find the 3D geometry for FEM to analyze the temperature distributions and 3D-printing to build the physical model for experiment. The results show that FEM predicted and experimentally measured temperatures have good agreement, which can be used to predict the temporal and spatial temperature distributions of the tissue and blood during the head and neck cooling process. Effects of boundary condition, perfusion, blood flow rate, and size of cooling area are studied. For head cooling, the cooling penetration depth is greatly depending on the blood perfusion in the brain. In the normal blood flow condition, the neck internal carotid artery temperature is decreased only by about 0.13°C after 60min of hypothermia. In an ischemic (low blood flow rate) condition, such temperature can be decreased by about 1.0°C. In conclusion, decreasing the blood perfusion and metabolic reduction factor could be more beneficial to cool the core zone. The results also suggest that more SBC researches should be explored, such as the optimization of simulation and experimental models, and to perform the experiment on human subjects.<br /> (Copyright © 2017 Elsevier Ltd. All rights reserved.)
- Subjects :
- Brain blood supply
Brain diagnostic imaging
Cerebrovascular Circulation
Finite Element Analysis
Head blood supply
Head diagnostic imaging
Heart Arrest prevention & control
Humans
Neck blood supply
Neck diagnostic imaging
Phantoms, Imaging
Printing, Three-Dimensional
Tomography, X-Ray Computed
Body Temperature
Brain physiology
Head physiology
Hypothermia, Induced
Models, Theoretical
Neck physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0306-4565
- Volume :
- 71
- Database :
- MEDLINE
- Journal :
- Journal of thermal biology
- Publication Type :
- Academic Journal
- Accession number :
- 29301706
- Full Text :
- https://doi.org/10.1016/j.jtherbio.2017.10.022