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Intrathecal antibody responses to GalC in Guillain-Barré syndrome triggered by Mycoplasma pneumoniae.
- Source :
-
Journal of neuroimmunology [J Neuroimmunol] 2018 Jan 15; Vol. 314, pp. 13-16. Date of Electronic Publication: 2017 Nov 16. - Publication Year :
- 2018
-
Abstract
- Mycoplasma pneumoniae (Mp) triggers Guillain-Barré syndrome (GBS) and elicits anti-galactocerebroside (GalC) antibodies. Specifically anti-GalC IgG is associated with Mp-GBS, possibly because of its better ability to cross the blood-nerve barrier (BNB). We here investigated CSF for the presence of anti-GalC in GBS. Intrathecal anti-GalC was found in 46% of Mp-GBS patients (n=6/13), in contrast to 16% of GBS controls (n=4/25) and 0% of non-GBS controls (n=0/7). The antibodies most likely originated from increased BNB permeability and/or intrathecal synthesis. Intrathecal anti-GalC IgG was specifically associated with Mp-GBS, further supporting that anti-GalC IgG contributes to the pathogenesis of GBS.<br /> (Copyright © 2017 Elsevier B.V. All rights reserved.)
- Subjects :
- Adolescent
Adult
Autoantibodies immunology
Autoantigens immunology
Female
Galactosylceramides immunology
Guillain-Barre Syndrome cerebrospinal fluid
Guillain-Barre Syndrome microbiology
Humans
Immunoglobulin G cerebrospinal fluid
Immunoglobulin G immunology
Male
Middle Aged
Pneumonia, Mycoplasma complications
Young Adult
Autoantibodies cerebrospinal fluid
Galactosylceramides cerebrospinal fluid
Guillain-Barre Syndrome immunology
Mycoplasma pneumoniae immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1872-8421
- Volume :
- 314
- Database :
- MEDLINE
- Journal :
- Journal of neuroimmunology
- Publication Type :
- Academic Journal
- Accession number :
- 29301655
- Full Text :
- https://doi.org/10.1016/j.jneuroim.2017.11.011