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HLA class I (-A, -B, -C) and class II (-DR, -DQ) polymorphism in the Mauritanian population.
- Source :
-
BMC medical genetics [BMC Med Genet] 2018 Jan 03; Vol. 19 (1), pp. 2. Date of Electronic Publication: 2018 Jan 03. - Publication Year :
- 2018
-
Abstract
- Background: HLA antigens have been widely studied for their role in transplantation biology, human diseases and population diversity. The aim of this study was to provide the first profile of HLA class I and class II alleles in the Mauritanian population.<br />Methods: HLA typing was carried in 93 healthy Mauritanian blood donors, using single specific primer amplification (PCR-SSP).<br />Results: Occurrences of the main HLA class I (-A, -B, -C) and class II (-DR, -DQ) antigens in the general population showed that out of the 17 HLA-A allele groups detected, five main HLA-A allele groups: A*02 (18.42%), A*01 (14.04%), A*23 (14.04%), A*30 (13.16%) and A*29 (12.28%) were the most common identified along other 12 relatively minor allele groups. Twenty three allele groups were observed in the locus B of which B*07 (13.46%) was the most prevalent followed by B*15, B*35, B*08 and B*27 all, with a frequency between 7 to 8%. Three prevalent HLA-C allele groups (C*02: 35.09%, C*07: 20.19% and C*06: 13.6%) were detected. The main HLA class II observed allele groups were: DRB1*13 (27.42%), DRB1*03 (24.73%), DRB1*11 (13.98%), DQB1*03 (36.03%), DQB1*02 (22.06%) and DQB1*05 (18.8%). Except for few haplotype in class I (A*02-B*07: 4.45%, A*02-C02: 10%, A*23-C*02: 8.8%, B*07-C*02: 8.8%, B*15-C*02: 8.8%) and in class II (DRB1*13-DQB1*06: 11.94%, DRB1*03-DQB1*02:11.19% and DRB1*03-DQB1*03: 10.45%), the majority of locus combination were in the range of 2-3%. A single predominant haplotype C*02-DRB1*03 (16.67%) was found.<br />Conclusions: These results, in agreement with previous data using different tissues markers, underlined the ethnic heterogeneity of the Mauritanian population.
- Subjects :
- Alleles
Female
Gene Frequency
Genetic Loci
HLA-DQ beta-Chains genetics
HLA-DRB1 Chains genetics
Haplotypes
Humans
Male
Mauritania
Phylogeography
Black People genetics
Genetics, Population
HLA-A Antigens genetics
HLA-B Antigens genetics
HLA-C Antigens genetics
HLA-D Antigens genetics
Polymorphism, Single Nucleotide
Subjects
Details
- Language :
- English
- ISSN :
- 1471-2350
- Volume :
- 19
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- BMC medical genetics
- Publication Type :
- Academic Journal
- Accession number :
- 29298671
- Full Text :
- https://doi.org/10.1186/s12881-017-0514-4