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Predictors of Obstructive Sleep Apnea in Consecutive Patients with Metabolic Syndrome.
- Source :
-
Metabolic syndrome and related disorders [Metab Syndr Relat Disord] 2018 Feb; Vol. 16 (1), pp. 2-5. Date of Electronic Publication: 2018 Jan 03. - Publication Year :
- 2018
-
Abstract
- Background: Recent evidence suggests that obstructive sleep apnea (OSA) is common in patients with metabolic syndrome (MetS) and may contribute to metabolic deregulation, inflammation, and atherosclerosis in these patients. In clinical practice, however, OSA is frequently underdiagnosed. We sought to investigate the clinical predictors of OSA in patients with MetS.<br />Methods: We studied consecutive patients newly diagnosed with MetS (Adult Treatment Panel-III). All participants underwent clinical evaluation, standard polysomnography, and laboratory measurements. We performed a logistic regression model, including the following variables: gender, age >50 years, neck and waist circumferences, hypertension, diabetes, body mass index (BMI) >30 kg/m <superscript>2</superscript> , high risk for OSA by Berlin questionnaire, presence of excessive daytime somnolence (Epworth Sleepiness Scale), abnormal serum glucose, triglycerides, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol.<br />Results: We studied 197 patients (60% men; age: 49 ± 10 years; BMI: 32.9 ± 5.1 kg/m <superscript>2</superscript> ). OSA (defined by an apnea-hypopnea index ≥15 events per hour) was diagnosed in 117 patients [59%; 95% confidence interval (CI): 52-66]. In multivariate analysis, male gender [odds ratio (OR): 3.28; 95% CI: 1.68-6.41; P < 0.01], abnormal glucose levels (OR: 3.01; 95% CI: 1.50-6.03; P < 0.01), excessive daytime sleepiness (OR: 2.38; 95% CI: 1.13-5.04; P = 0.02), and high risk for OSA by Berlin questionnaire (OR: 4.33; 95% CI: 2.06-9.11; P < 0.001) were independently associated with OSA.<br />Conclusions: Simple clinical and metabolic characteristics may help to improve the underdiagnosis of OSA in patients with MetS.
- Subjects :
- Adult
Biomarkers blood
Female
Humans
Male
Metabolic Syndrome blood
Metabolic Syndrome diagnosis
Metabolic Syndrome physiopathology
Middle Aged
Risk Factors
Sleep Apnea, Obstructive blood
Sleep Apnea, Obstructive diagnosis
Sleep Apnea, Obstructive physiopathology
Energy Metabolism
Lung physiopathology
Metabolic Syndrome complications
Respiration
Sleep
Sleep Apnea, Obstructive etiology
Subjects
Details
- Language :
- English
- ISSN :
- 1557-8518
- Volume :
- 16
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Metabolic syndrome and related disorders
- Publication Type :
- Academic Journal
- Accession number :
- 29298404
- Full Text :
- https://doi.org/10.1089/met.2017.0112